gliquidone rapidly and almost completely absorbed from the gastrointestinal tract. After ingestion Primobolan depot for salea single dose (30 mg), the maximum plasma concentrations achieved within 2-3 hours, is 500-700 ng / mL and 14.1 hour after dropping 50%. Fully metabolized by the liver. The bulk of the metabolites excreted in the bile and through the intestines. Only a small part of metabolites excreted in the urine. Regardless of the dose and mode of administration, the urine is detected in about 5% (as metabolites) of the drug amount administered. The level of excretion by the kidneys Primobolan depot for salea remains minimal, even with the regular appointment.
Type 2 diabetes mellitus in middle-aged and elderly patients (with the poor diet).
- Hypersensitivity to sulfonylureas or sulfonamides;
- Diabetes mellitus type 1;
- diabetic ketoacidosis, precoma, coma;
- state after pancreatic resection;
- acute hepatic porphyria,
- severe liver function;
- some acute conditions (eg, infectious diseases or major surgery, when shown holding insulin);
- pregnancy, breastfeeding.Precautions
Primobolan depot for sale should be applied:
- feverish syndrome;
- diseases of the thyroid gland (with dysfunction);
- alcoholism.Pregnancy and lactation
Application Primobolan depot for salea during pregnancy is contraindicated.
In case of pregnancy, you should stop taking the drug and seek immediate medical attention.
If necessary, use during breast-feeding, breast-feeding should be discontinued.
Dosing and Administration
The drug is administered orally.
Dose selection and reception mode must be carried out under the control of carbohydrate metabolism. Primobolan depot for salea initial dose is usually 14 tablets (15 mg) at breakfast. If necessary, increase the dose gradually, according to the doctor’s recommendations. Increasing the dose to 4 tablets (120 mg) per day normally does not lead to further enhance the effect. If Primobolan depot for salea daily dose does not exceed 2 tablets (60 mg), it can be administered at once, during breakfast. When assigning a higher dose, the best effect can be obtained when taking the daily dose divided into 2-3 doses. In this case, the highest dose should be taken at breakfast. Primobolan depot for sale should be taken with food, at the beginning of a meal. If you are replacing an oral primobolan depot for sale agent with a similar mechanism of action starting dose is determined depending on the disease at the time of drug administration. The initial dose is usually 1 / 2-1 tablet (15-30 mg). If monotherapy does not provide the desired effect, possible additional appointment biguanide.
Interactions with other drugs
salicylates, sulfonamides, derivatives phenylbutazone, anti-TB drugs, chloramphenicol, tetracyclines and coumarin derivatives, cyclophosphamide, MAO inhibitors, ACE inhibitors, clofibrate, β-blockers, sympatholytic (clonidine), reserpine, guanethidine, other primobolan depot for sale agents may increase the primobolan depot for sale effect of sulfonylureas.
May decrease primobolan depot for sale action, while the appointment Primobolan depot for salea and sympathomimetics, corticosteroids, thyroid hormones, glucagon, thiazide diuretics, oral contraceptives, diazoxide, phenothiazine and preparations containing nicotinic acid, barbiturates, rifampicin, phenytoin. Strengthening or weakening effect has been described when taking H 2 blockers (cimetidine, ranitidine) and alcohol.
must be strictly followed medical recommendations aimed at normalization of glucose metabolism in the patient. You should not stop treatment on their own, without telling your doctor. Although Primobolan depot for sale excreted in the urine slightly (5%), and is generally well tolerated in renal disease, treatment of patients with severe renal insufficiency should be under close medical supervision.
Patients with diabetes are prone to the development of cardiovascular disorders, the risk of which can be reduced only with strict adherence to the prescribed diet. Oral primobolan depot for sale agents should not replace medical diet that allows you to monitor the patient’s body weight. All oral primobolan depot for sale agents in food intake are delayed or non-recommended dosing regimen can lead to a significant reduction in blood glucose level and the development of a primobolan depot for sale condition. The use of sugar, sweets or sugary drinks usually helps prevent starting primobolan depot for sale reaction. In the case of persistent primobolan depot for sale condition should consult a doctor immediately.
In case of feeling unwell (fever, rash, nausea) during Primobolan depot for saleom treatment should consult a doctor immediately.
In case of allergic reactions, you should stop taking Primobolan depot for salea, replacing it with other primobolan depot for sale drugs or insulin.
Effects on ability to drive vehicles and management mechanisms
In the period of dose adjustment or change the drug should avoid activities potentially hazardous activities that require increased attention and psychomotor speed reactions.
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