methenolone enanthate side effects

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Methenolone enanthate side effects antibiotic that is effective against fungi of the genus Trichophyton, Microsporum, Epydermophyton Achorionum; is a violation of the mitotic spindle structure and cell wall synthesis in chitin-containing fungi suppresses the division of fungal cells in metaphase and protein synthesis due to the breakdown in communication with the messenger RNA. It accumulates in the skin, hair and nails, which are the precursors of keratin, making keratin resistant to fungal infestation. As separating infected keratin is a replacement of his healthy tissue.  Absorption РHigh: microcrystalline form Р25-70%, ultramikrokristallicheskaya form Рalmost 100%. Eating fat increases the absorption. Time to maximum drug concentration in plasma after ingestion -4-5 h, the maximum drug concentration in plasma Р0.5-5 mg / l. Communication with plasma proteins Р80%. Selectively accumulates in the stratum corneum and its appendages, and in the liver, adipose tissue, skeletal muscle. A small number distributed in body fluids and tissues. It penetrates through the placenta. It is metabolized in the liver to inactive metabolites (6-metilgri zeofulvina and glucuronide derivative). The half-life of the drug -. 24 hours excreted by the kidneys (including 1% Рunchanged) and through the intestine (36% unchanged).

 

Indications
of skin fungal infections, hair and nails (favus, trihofitia, mikrosporiya scalp mikrosporiya smooth skin, beard and mustache ringworm, athlete’s smooth skin, jock itch, onychomycosis).

Contraindications:
Hypersensitivity, porphyria, systemic lupus erythematosus, lupus-like syndrome, systemic blood diseases, leukopenia, organic liver and kidney disease, liver failure, cancer, pregnancy, lactation, children’s age (up to 2 years – efficacy and safety have not been studied).

Dosing and Administration
Inside, during or after a meal, in one or more steps. Adults – a daily dose of 500 mg. In severe mycosis dose increased. Babies – a daily dose of 10 mg / kg.
The duration of treatment for serious mycoses – up to 12 months. The course of treatment in lesions of the skin of the body – 2-4 weeks, the scalp – 4-6 weeks, stop – 4-8 weeks, the fingers – not less than 4 months, the toes – at least 6 months. The highest daily dose of -1

Side effect On the part of the nervous system : headache, dizziness, weakness, fatigue, insomnia, peripheral neuropathy, impaired coordination, confusion, paresthesia of extremities, confusion From the digestive system : nausea, vomiting, diarrhea, gastralgia, oral candidiasis, hepatitis From the of hematopoiesis : granulocytopenia, agranulocytosis, leukopenia, allergic reaction: hives, skin rash, pruritus, angioedema, photosensitivity, lupus-like syndrome, erythema multiforme, toxic epidermal necrolysis (Lyell’s syndrome).

 

Interaction with other drugs
increases the effects of ethanol.
Reduces activity estrogensoderjath oral contraceptives, anticoagulants indirect type of action as a result of induction of microsomal liver enzymes.
Barbiturates and primidone reduce the methenolone enanthate side effects activity.

Special instructions
Due to the negative impact on reproductive function (both men and women) need to use effective non-hormonal methods of contraception.
Patients should refrain from activities potentially hazardous activities that require increased attention and psychomotor speed reactions.
Griseofulvin is not used to treat lung infections severity level at which the appointment is sufficient only methenolone enanthate side effects agent for external use.

Form release
Tablets 125 mg.
10 tablets in blisters.
By 2 blisters with instruction for use in a stack of cardboard.

Storage conditions
List B. In dry, place inaccessible to children at temperature not above 20 ¬į C.

Shelf life
3 years 6 months. After the expiry date does not apply. how much to inject for weight loss

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