Hypersensitivity to the drug or excipients, the hypothalamic-pituitary tumors. In women: pregnancy, bulky tumors or bayer primobolan depot cysts (not due to polycystic ovary syndrome), uterine bleeding of unknown etiology, bayer primobolan depot cancer, uterine cancer, breast cancer. The drug should not be given:
- women: the anomalies of the genitals and uterine fibroids incompatible with pregnancy, primary ovariapnoy failure, premature menopause.
- men: the primary testicular failure.
Use during pregnancy and lactation
During pregnancy and breastfeeding drug Gonal-F is not assigned.
Dosing and Administration:
Inject subcutaneously. Women. In anovulatory infertility with preserved menstrual cycle or in violation of its periodicity. Treatment starts in the first 7 days of the cycle. Stimulation is performed under ultrasound guidance (measured dimensions of follicles) and / or the level of estrogen in the blood. Stimulation begins with a daily dose of 75-150 ME (0.13-0.25 mL), increasing to 37.5 -75 ME ME 7 intervals, or (preferably) 14 days until the desired effect. The maximum dose of one injection should not exceed 225 ME (0.38 mL). In the absence of positive dynamics after 4 weeks, treatment should be stopped. In the next cycle, the stimulation should be initiated at a higher dose. After the optimum size of follicles 24-48 hours after the last injection GONAL-f ® singly administered 250 ug horiogonadotropina recombinant human (r-hCG) or ME 000 5000-10 human chorionic gonadotropin ( hCG). On the day of the hCG injection and the next day the patient is recommended sexual contact. In case of an excessive bayer primobolan depot response to stimulation by administration of hCG should be abolished. In the next cycle prescribed a lower than the previous dose. When conducting controlled bayer primobolan depot hyperstimulation for assisted reproductive technologies. Gonal-f ® administered daily 150-225 ME (0.25-0.38 mL), starting from the 2-3 day cycle. The daily dose may vary, but generally does not exceed 450 ME (0.75 ml). Treatment continued until a follicle of adequate size by ultrasound (an average of 5-20 days). 24-48 hours after the last injection GONAL-f ® singly administered 250 mcg r-hCG or hCG 5000-10 ME 000 to induce final follicular maturation. In order to suppress endogenous luteinizing hormone release hormone (LH) and maintaining it at a low level using analogs of gonadotropin -rilizing hormone. in anovulatory infertility with the absence of the menstrual cycle as a result of deficiency of FSH and luteinizing hormone. The dose and regimen selected by the doctor individually. Usually, Gonal-f ® administered subcutaneously daily for up to 5 weeks along with luteinizing hormone. Treatment of Gonal-f ® are starting with a dose of 75-150 ME (0.13-0.25 ml) simultaneously with lutropinom alfa at a dose 75 ME. If necessary, the dose of Gonal-f ® may be increased by 37.5 ME – 75 ME every 7-14 days. In the absence of adequate response to stimulation for 5 weeks, therapy should be stopped and resume in the new cycle at a higher dose.After reaching the optimal size of the follicle / follicles 24-48 hours after the last injection of Gonal-f ® and alpha lutropina once administered 250 micrograms r-hCG or hCG 5000-10 000 ME. On the day of the hCG injection and the next day the patient recommend sexual intercourse. Alternatively, it may be carried out intrauterine insemination. In the case of an excessive bayer primobolan depot response to stimulation treatment should be discontinued, and to revoke the appointment of hCG. The stimulation was repeated in the next cycle, beginning with lower compared to the previous cycle dose. Men. Men usually prescribed GONAL-f ® in a dose of 150 ME (0.25 ml) three times a week for at least 4 months in combination with hCG. If there is no positive effect during this time ,, the treatment may be continued until 18 months.
When using the drug Gonal-f ® may develop side effects, which, depending on the frequency of occurrence are regarded as very rare (<1/10000 cases primeieniya), rare (> 1/10000 at <1/1000), frequent ( > 1/100 at <1/1000), very frequent (> 1/10 <1/100). The use of women Local reactions: often mild / moderate severity of injection site reactions (pain, redness, bruising, swelling .) Central nervous system: often -Head pain Reproductive system and breasts: very often – bayer primobolan depot cysts; often – bayer primobolan depot hyperstimulation syndrome (OHSS) mild or moderate severity, rarely -Heavy form of bayer primobolan depot hyperstimulation syndrome, bayer primobolan depot cyst torsion (as a complication of bayer primobolan depot hyperstimulation syndrome), bayer primobolan depot apoplexy, ectopic pregnancy (in women with a history of tubal disease), multiple pregnancy (see .Special instructions). Mild OHSS is accompanied by pain in the abdomen, nausea, vomiting, weight gain, increase in bayer primobolan depot, including through the formation of cysts. In moderate and severe form of OHSS also marked dyspnea, oliguria, ascites, hydrothorax, pleural effusion, an accumulation of fluid in the pericardial cavity. There are acute pulmonary insufficiency, thromboembolism. Gastrointestinal tract: often – abdominal pain, nausea, vomiting, diarrhea, colic, belching. The vascular system: very rarely – increased blood clotting (thrombosis), pulmonary embolism, ischemic stroke, myocardial infarction. respiratory system: very rarely in patients with bronchial asthma – worsening or exacerbation of the disease. The immune system: very rare – Mild systemic allergic reactions (redness, rash, swelling of the face, hives, difficulty breathing), the development of severe allergic reactions, including . anaphylaxis Other: fever, arthralgia. Application men Local reactions: often – a reaction mild / moderate severity at the injection site (pain, redness, bruising, swelling). Skin and subcutaneous tissue: often – acne (acne). Reproductive system and breasts: . frequently – gynecomastia, varicocele Other: . frequently – weight gain When serious adverse effects or effects that are not described above, you must report it to your doctor. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo.